The Science

Quatrefolic® & The Folate Problem

Bioavailability and Direct Utilization Studies

• Folate, folic acid and 5-methyltetrahydrofolate are not the same thing https://pubmed.ncbi.nlm.nih.gov/24494987/

• Quatrefolic®: A New Generation of Folate for Better Health and Well-being https://www.researchgate.net/publication/262604043_QuatrefolicR_A_New_Generation_of_Folate_for_Better_Health_and_Well-being

• Pharmacokinetics of a novel folate, Quatrefolic, in healthy volunteers https://pubmed.ncbi.nlm.nih.gov/21849102/

• Comparison of bioavailability of Quatrefolic with folic acid in healthy human subjects https://ijap.journals.ekb.eg/article_341999.html

MTHFR Variant Prevalence and "The Folate Problem"

• The MTHFR 677C-->T polymorphism: A common genetic risk factor for cardiovascular disease? https://pubmed.ncbi.nlm.nih.gov/11681907/

• MTHFR gene variations: The role of folate and vitamin B12 in health and disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262611/

• Prevalence of the C677T polymorphism of the methylenetetrahydrofolate reductase gene https://pubmed.ncbi.nlm.nih.gov/11261545/

Clinical Outcomes and Efficacy Comparison

• Quatrefolic® vs. Folic Acid: A Comparative Study on Homocysteine Lowering https://pubmed.ncbi.nlm.nih.gov/27083545/

• Active Folate vs. Folic Acid: The Benefits of 5-MTHF for Maternal Health https://pubmed.ncbi.nlm.nih.gov/21262704/

Unmetabolized Folic Acid (UMFA) Concerns

• Folic Acid Supplementation and the Appearance of Unmetabolized Folic Acid in Serum https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287316/

• Circulating Unmetabolized Folic Acid: Relationship to Folate Intake and Status https://pubmed.ncbi.nlm.nih.gov/25578393/
  
  

Quatrefolic® is a registered trademark of Gnosis S.p.A., U.S. Patent No. 7,947,662.

Methylcobalamin vs. Cyanocobalamin

Comparative Bioavailability and Tissue Retention

• Comparative bioavailability of methylcobalamin and cyanocobalamin https://pubmed.ncbi.nlm.nih.gov/3382221/

• Vitamin B12: Dietary Intake, Bioavailability and Absorption https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8309106/

• Absorption and tissue distribution of various forms of vitamin B12 https://pubmed.ncbi.nlm.nih.gov/5560708/

Neurological Function and Clinical Support

• Methylcobalamin: A Potential Therapeutic Agent for Neuropathic Pain https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412422/

• Vitamin B12 in Neurology and Aging: Clinical and Genetic Aspects https://pubmed.ncbi.nlm.nih.gov/24716117/

• Effects of Vitamin B12 on Neurological and Mental Disorders https://pubmed.ncbi.nlm.nih.gov/22648725/

Conversion and Metabolic Efficiency

• The Metabolic Role of Methylcobalamin in the Human Body https://pubmed.ncbi.nlm.nih.gov/11364231/

• Comparative study of cyanocobalamin and methylcobalamin on the urinary excretion of B12 https://pubmed.ncbi.nlm.nih.gov/6703080/

• Cobalamin coenzyme forms and their biological significance https://pubmed.ncbi.nlm.nih.gov/16543665/

Stability and Safety Profiles

• Stability and delivery of methylcobalamin in clinical formulations https://pubmed.ncbi.nlm.nih.gov/23247131/
  

These studies are provided for educational and transparency purposes. They are not intended to imply that ELIKSR diagnoses, treats, cures, or prevents any disease. Individual results may vary.